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Cabozantinib inhibits growth of androgen-sensitive and castration-resistant prostate cancer and affects bone remodeling.

Cabozantinib is an inhibitor of multiple receptor tyrosine kinases, including MET and VEGFR2. In a phase II clinical trial in advanced prostate cancer (PCa), cabozantinib treatment improved bone scans in 68% of evaluable patients. Our studies aimed to determine the expression of cabozantinib targets...

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Principais autores: Holly M Nguyen, Nazanin Ruppender, Xiaotun Zhang, Lisha G Brown, Ted S Gross, Colm Morrissey, Roman Gulati, Robert L Vessella, Frauke Schimmoller, Dana T Aftab, Eva Corey
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2013-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3808282?pdf=render
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