Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4,6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl]pyrrolo[3,4-<i>c</i>]pyrrole-1,3(2<i>H</i>,5<i>H</i>)-diones as Anti-Inflammatory Agents with Dual Inhibition of COX and LOX

In the present study, we characterize the biological activity of a newly designed and synthesized series of 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl] derivatives of pyrrolo[3,4-<i>c</i>]pyrrole <b>3a</b>–<b>3o</b>. The compounds were obtained with good yields of pyrrolo[3,4-<i...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Aleksandra Redzicka, Benita Wiatrak, Izabela Jęśkowiak-Kossakowska, Andrzej Kochel, Remigiusz Płaczek, Żaneta Czyżnikowska
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-05-01
Schriftenreihe:	Pharmaceuticals
Schlagworte:	pyrrolo[3,4-<i>c</i>]pyrrole cyclooxygenase inhibition COX-1/COX-2 LOX molecular docking analgesic activity anti-inflammatory
Online-Zugang:	https://www.mdpi.com/1424-8247/16/6/804
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!