Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4,6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl]pyrrolo[3,4-<i>c</i>]pyrrole-1,3(2<i>H</i>,5<i>H</i>)-diones as Anti-Inflammatory Agents with Dual Inhibition of COX and LOX

In the present study, we characterize the biological activity of a newly designed and synthesized series of 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl] derivatives of pyrrolo[3,4-<i>c</i>]pyrrole <b>3a</b>–<b>3o</b>. The compounds were obtained with good yields of pyrrolo[3,4-<i...

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Hlavní autoři:	Aleksandra Redzicka, Benita Wiatrak, Izabela Jęśkowiak-Kossakowska, Andrzej Kochel, Remigiusz Płaczek, Żaneta Czyżnikowska
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-05-01
Edice:	Pharmaceuticals
Témata:	pyrrolo[3,4-<i>c</i>]pyrrole cyclooxygenase inhibition COX-1/COX-2 LOX molecular docking analgesic activity anti-inflammatory
On-line přístup:	https://www.mdpi.com/1424-8247/16/6/804
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