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Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity

Abstract Background Alzheimer’s disease (AD) is characterized by chronic neuroinflammation alongside amyloid-beta plaque and phosphorylated tau (p-Tau) tangle accumulation. Microglia, as resident immune cells, undergo glycolytic reprogramming that may exacerbate inflammation and impede toxic protein...

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Principais autores: Ning Lu, Zhongman Jin, Nian Liu, Caiyun Zhu, Hui Wei, Qi Xu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-10-01
coleção:Journal of Neuroinflammation
Assuntos:
Microglia
Alzheimer’s disease
Glycolysis
PKM2
Neuroinflammation
Acesso em linha:https://doi.org/10.1186/s12974-025-03546-9
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