Co-differentiation and enrichment of corneal endothelial cells and keratocytes from human pluripotent stem cells

Abstract Corneal keratocytes (CK) and endothelial cells (CEnC) maintain corneal stromal transparency. Damage to these cell types can lead to visual impairment. Although corneal transplantation is effective, donor shortages limit its availability. Human pluripotent stem cells (hPSC) offer a promising...

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Autori principali: Abhinav Reddy Kethiri, Pyry Grönroos, Ajai Suwaraj Chinnaiah Nagaraj, Heli Skottman
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-05-01
Serie:Scientific Reports
Soggetti:
Cornea
Stroma
Keratocytes
Endothelium
Pluripotent stem cell
Differentiation
Accesso online:https://doi.org/10.1038/s41598-025-03509-3
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