Cleavage of MALAT1 RNA by 14-nt sgRNA-guided tRNase ZL.
We have been developing a gene suppression technology, tRNase ZL-utilizing efficacious (TRUE) gene silencing, in which artificially designed small guide RNA (sgRNA) guides tRNase ZL to cleave cellular target RNA. In this study, we examined 14-nt linear-type sgRNAs, which are fully 2'-O-methylated an...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science (PLoS)
2025-01-01
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| Collection: | PLoS ONE |
| Accès en ligne: | https://doi.org/10.1371/journal.pone.0318968 |
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