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Iron-Deficiency Anemia Results in Transcriptional and Metabolic Remodeling in the Heart Toward a Glycolytic Phenotype

Iron deficiency is the most prevalent micronutrient disorder globally. When severe, iron deficiency leads to anemia, which can be deleterious to cardiac function. Given the central role of iron and oxygen in cardiac biology, multiple pathways are expected to be altered in iron-deficiency anemia, and...

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Principais autores: Yu Jin Chung, Pawel Swietach, M. Kate Curtis, Vicky Ball, Peter A. Robbins, Samira Lakhal-Littleton
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-01-01
Serier:Frontiers in Cardiovascular Medicine
Fag:
iron deficiency
anemia
hypoxia
RNA-Seq
cardiac transcriptome
cardiac metabolism
Online adgang:https://www.frontiersin.org/articles/10.3389/fcvm.2020.616920/full
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