The Remaining Conundrum of the Role of the Na+/H+ Exchanger Isoform 1 (NHE1) in Cardiac Physiology and Pathology: Can It Be Rectified?

The mammalian Na+/H+ exchanger (NHE) is a family of ubiquitous membrane proteins present in humans. Isoform one (NHE1) is present on the plasma membrane and regulates intracellular pH by removal of one intracellular proton in exchange for one extracellular sodium thus functioning as an electroneutra...

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Detalhes bibliográficos

Principais autores:	Morris Karmazyn, Grant N. Pierce, Larry Fliegel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	IMR Press 2022-08-01
coleção:	Reviews in Cardiovascular Medicine
Assuntos:	nhe1 regulation nhe1 inhibitors cardiac hypertrophy and remodelling ischemia/reperfusion injury pyrazinoyl guanidine
Acesso em linha:	https://www.imrpress.com/journal/RCM/23/8/10.31083/j.rcm2308284
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