Challenges of aortic valve tissue culture – maintenance of viability and extracellular matrix in the pulsatile dynamic microphysiological system

Abstract Background Calcific aortic valve disease (CAVD) causes an increasing health burden in the 21st century due to aging population. The complex pathophysiology remains to be understood to develop novel prevention and treatment strategies. Microphysiological systems (MPSs), also known as organ-o...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Claudia Dittfeld, Maximilian Winkelkotte, Anna Scheer, Emmely Voigt, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag, Sems-Malte Tugtekin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-09-01
Schriftenreihe:	Journal of Biological Engineering
Schlagworte:	Calcific aortic valve disease Tissue culture Microphysiological system Viability ECM remodelling
Online-Zugang:	https://doi.org/10.1186/s13036-023-00377-1
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