Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions

A novel flow-based approach for the preparation of benzimidazol-2-one (<b>1</b>) scaffold by the 1,1&#8242;-carbonyldiimidazole (CDI)-promoted cyclocarbonylation of <i>o</i>-phenylenediamine (<b>2</b>) is reported. Starting from a preliminary batch screening, the model reaction was successfully tran...

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Hlavní autoři:	Serena Mostarda, Tugçe Gür Maz, Alessandro Piccinno, Bruno Cerra, Erden Banoglu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2019-07-01
Edice:	Molecules
Témata:	flow chemistry statistical experimental design benzimidazol-2-one
On-line přístup:	https://www.mdpi.com/1420-3049/24/13/2447
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