HTLV-1 Tax and HBZ cooperatively promote leukemogenesis through miR-155-mediated PTEN suppression and PI3K-Akt activation
ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL), but the full scope of its oncogenic mechanisms remains elusive. While the viral oncoprotein Tax drives early oncogenesis, its expression is frequently silenced in later stages of ATLL, whereas the HTLV...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2026-06-01
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| Col·lecció: | Journal of Virology |
| Matèries: | |
| Accés en línia: | https://journals.asm.org/doi/10.1128/jvi.00554-26 |
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