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HTLV-1 Tax and HBZ cooperatively promote leukemogenesis through miR-155-mediated PTEN suppression and PI3K-Akt activation

ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL), but the full scope of its oncogenic mechanisms remains elusive. While the viral oncoprotein Tax drives early oncogenesis, its expression is frequently silenced in later stages of ATLL, whereas the HTLV...

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Principais autores: Xiaoru Xin, Yu Mao, Qianan Li, Xinyi Wang, Jinyong Fang, Tiejun Zhao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-06-01
Serier:Journal of Virology
Fag:
HTLV-1
ATLL
miR-155
HBZ
Tax
PTEN
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00554-26
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