G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic data

Abstract RNA G-quadruplexes (rG4s) are key regulatory elements in gene expression, yet the effects of genetic variants on rG4 formation remain underexplored. Here, we introduce G4mer, an RNA language model that predicts rG4 formation, classifies rG4 subtypes, and evaluates the effects of genetic var...

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Detalhes bibliográficos

Principais autores:	Farica Zhuang, Danielle Gutman, Nathaniel Islas, Bryan B. Guzman, Alli Jimenez, San Jewell, Nicholas J. Hand, Katherine Nathanson, Daniel Dominguez, Yoseph Barash
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-65020-7
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