Pharmacological inhibition of PLK1/PRC1 triggers mitotic catastrophe and sensitizes lung cancers to chemotherapy

Abstract Polo-like kinase 1 (PLK1) signaling drives tumor malignancy and chemotherapy resistance, which is an unmet clinical need. Recruiting PLK1 to the central spindle during anaphase is necessary for its function in promoting cancer cell proliferation, which is achieved by binding to microtubule-...

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Autors principals:	Pingping Li, Yufei Zhao, Minghan Lu, Chengfei Chen, Yongkun Li, Lingling Wang, Shulan Zeng, Yan Peng, Hong Liang, Guohai Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2025-05-01
Col·lecció:	Cell Death and Disease
Accés en línia:	https://doi.org/10.1038/s41419-025-07708-8
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