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A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe

In this study, we designed, synthesized and evaluated, in vitro, novel chalcone analogs containing dialkylamino pharmacophores in the cervical cancer cell line, OV2008. The compound, <b>DML6</b> was selective and significantly decreased the proliferation of OV2008 and HeLa cells in sub-micromolar co...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jenna M. Len, Noor Hussein, Saloni Malla, Kyle Mcintosh, Rahul Patidar, Manivannan Elangovan, Karthikeyan Chandrabose, N. S. Hari Narayana Moorthy, Manoj Pandey, Dayanidhi Raman, Piyush Trivedi, Amit K. Tiwari
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-07-01
Schriftenreihe:Molecules
Schlagworte:
cervical cancer
chalcone
dialkylamino
intrinsic apoptosis
mitotic catastrophe
drug discovery
Online-Zugang:https://www.mdpi.com/1420-3049/26/14/4214
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