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Unique characteristics of the J-domain proximal regions of Hsp70 cochaperone Apj1 in prion propagation/elimination and its overlap with Sis1 function

J-domain proteins (JDPs) are obligate cochaperones of Hsp70s. The Class A JDP Apj1 of the yeast cytosol has an unusually complex region between the N-terminal J-domain and the substrate binding region—often called the Grich or GF region in Class A and B JDPs because of its typical abundance of glyci...

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Principais autores: Samantha J. Ganser, Bridget A. McNish, Gillian L. Schwanitz, John L. Delaney, Bridget A. Corpus, Brenda A. Schilke, Anup K. Biswal, Chandan Sahi, Elizabeth A. Craig, Justin K. Hines
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-04-01
Serier:Frontiers in Molecular Biosciences
Fag:
chaperone
amyloid
Hsp104
Hsp40
J-protein
Online adgang:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1392608/full
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