Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions
Abstract Background Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive deficits due to impairment of AMPA and NMDA receptor recycling. Studies...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BMC
2024-01-01
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| Series: | Immunity & Ageing |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1186/s12979-023-00402-3 |
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