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Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions

Abstract Background Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive deficits due to impairment of AMPA and NMDA receptor recycling. Studies...

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Principais autores: Cristina Rodriguez-Rodriguez, Natalia González-Mancha, Ane Ochoa-Echeverría, Rosa Liébana, Isabel Merida
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-01-01
Serier:Immunity & Ageing
Fag:
Aging
Down syndrome
Cytokines
Lymphocyte
Inflammation
SNX27
Online adgang:https://doi.org/10.1186/s12979-023-00402-3
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