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Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.

The menaquinone biosynthetic pathway presents a promising drug target against Mycobacterium tuberculosis and potentially other Gram-positive pathogens. In the present study, the essentiality, steady state kinetics of MenA from M. tuberculosis and the mechanism of MenA inhibition by Ro 48-8071 were c...

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Principais autores: Rakesh K Dhiman, Venugopal Pujari, James M Kincaid, Melanie A Ikeh, Tanya Parish, Dean C Crick
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2019-01-01
סדרה:PLoS ONE
גישה מקוונת:https://doi.org/10.1371/journal.pone.0214958
תגים: הוספת תג
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