Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux through ATP-citrate lyase (ACLY) to reduce cy...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI AG
2021-04-01
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| Colección: | Antioxidants |
| Materias: | |
| Acceso en línea: | https://www.mdpi.com/2076-3921/10/4/572 |
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