Neuroimaging evaluation of high dose methotrexate-induced neurotoxicity in pediatric and young adults: a PET/MRI study

IntroductionHigh-dose Methotrexate (HDMTX) can induce neurotoxicity, yet its impact on brain metabolism remains underexplored. This study aimed to assess short- and long-term brain metabolic changes post-HDMTX on 18F-FDG PET/MRI relative to baseline (pre-HDMTX) scans.MethodsIn this IRB approved, ret...

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Autori principali:	Zahra Shokri Varniab, Hyun Gi Kim, Ricarda von Krüchten, Yashas Ullas Lokesha, Kristina Elizabeth Hawk, Shashi Bhushan Singh, Tie Liang, Sarah Lu-Liang, Lucia Baratto, Michael Iv, Heike Elisabeth Daldrup-Link
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-01-01
Serie:	Frontiers in Neuroimaging
Soggetti:	cancer survivors methotrexate neurotoxicity pediatric oncology PET
Accesso online:	https://www.frontiersin.org/articles/10.3389/fnimg.2025.1659480/full
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