Neuroimaging evaluation of high dose methotrexate-induced neurotoxicity in pediatric and young adults: a PET/MRI study

IntroductionHigh-dose Methotrexate (HDMTX) can induce neurotoxicity, yet its impact on brain metabolism remains underexplored. This study aimed to assess short- and long-term brain metabolic changes post-HDMTX on 18F-FDG PET/MRI relative to baseline (pre-HDMTX) scans.MethodsIn this IRB approved, ret...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Zahra Shokri Varniab, Hyun Gi Kim, Ricarda von Krüchten, Yashas Ullas Lokesha, Kristina Elizabeth Hawk, Shashi Bhushan Singh, Tie Liang, Sarah Lu-Liang, Lucia Baratto, Michael Iv, Heike Elisabeth Daldrup-Link
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
Colecção:	Frontiers in Neuroimaging
Assuntos:	cancer survivors methotrexate neurotoxicity pediatric oncology PET
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnimg.2025.1659480/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!