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Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement system. In more than half of C3G patients C3...

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Gorde:
Egile Nagusiak: Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Ramon M. van den Bos, Thea J. A. M. van der Velden, Sanne A. W. van Kraaij, Sebastian A. Sarlea, Valentina Gracchi, Michiel J. S. Oosterveld, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2019-06-01
Saila:Frontiers in Immunology
Gaiak:
complement system
alternative pathway
convertase
properdin
C3 nephritic factor
C3 glomerulopathy
Sarrera elektronikoa:https://www.frontiersin.org/article/10.3389/fimmu.2019.01350/full
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