Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by dysregulation of the alternative pathway (AP) of the complement system. C3G is often associated with autoantibodies stabilizing the AP C3 convertase named C3 nephritic factors (C3NeF). The role of classical pathwa...

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Auteurs principaux:	Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Sanne A. W. van Kraaij, Sebastian A. Sarlea, Valentina Gracchi, Flore A. P. T. Engels, Eiske M. Dorresteijn, Johannes van der Deure, Caroline Duineveld, Jack F. M. Wetzels, Lambertus P. W. J. van den Heuvel, Elena B. Volokhina
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2021-08-01
Collection:	Frontiers in Immunology
Sujets:	C3 glomerulopathy classical complement pathway autoantibody C3 convertase C4 nephritic factors (C4NeFs) C3 nephritic factors (C3NeFs)
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.715704/full
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