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Combined Bisoprolol and Megestrol Acetate Improves Survival and Preserves Cardiac Performance in a Rat Model of Cancer Cachexia

ABSTRACT Background Cancer cachexia is associated with rapid body wasting and cardiac dysfunction. Bisoprolol (BIS) and megestrol acetate (MA) improve selected cachexia phenotypes in the Yoshida AH‐130 model, but their combined effects are not defined. We tested reduced‐dose combined treatment of BI...

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Principais autores: Zihao Chen, Siqi Wang, Sandra Palus, Stefan D. Anker, Wolfram Doehner, Jochen Springer
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2026-06-01
coleção:Journal of Cachexia, Sarcopenia and Muscle
Assuntos:
body composition
body weight
cancer cachexia
cardiac function
heart
survival
Acesso em linha:https://doi.org/10.1002/jcsm.70313
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