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A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6

Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATP-competitive inhibitor of PGK1 w...

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Principais autores: Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-11-01
coleção:Acta Pharmaceutica Sinica B
Assuntos:
Glycolysis
Phosphoglycerate kinase1
Macrophages
NRF2
Inflammation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383522002192
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