LDHC4 promotes ovarian cancer progression through H4K12 lactylation to regulate PGK1 expression and modulate glycolysis
Abstract Objective Ovarian cancer (OC) pathogenesis involves metabolic and epigenetic alterations, yet the underlying mechanisms remain unclear. Here, we sought to investigate the role and regulatory mechanism of lactate dehydrogenase C4 (LDHC4) in OC progression. Methods Multi-omics approaches were...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BMC
2026-02-01
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| Collection: | Journal of Translational Medicine |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1186/s12967-026-07695-0 |
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