Elevated branched-chain amino acid promotes atherosclerosis progression by enhancing mitochondrial-to-nuclear H2O2-disulfide HMGB1 in macrophages

As the essential amino acids, branched-chain amino acid (BCAA) from diets is indispensable for health. BCAA supplementation is often recommended for patients with consumptive diseases or healthy people who exercise regularly. Latest studies and ours reported that elevated BCAA level was positively c...

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Main Authors:	Shuai Zhao, Lei Zhou, Qin Wang, Jia-Hao Cao, Yan Chen, Wei Wang, Bo-Da Zhu, Zhi-Hong Wei, Rong Li, Cong-Ye Li, Geng-Yao Zhou, Zhi-Jun Tan, He-Ping Zhou, Cheng-Xiang Li, Hao-Kao Gao, Xu-Jun Qin, Kun Lian
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2023-06-01
Series:	Redox Biology
Subjects:	Atherosclerosis (AS) Branched-chain amino acid (BCAA) Macrophage Inflammation Hydrogen peroxide (H2O2) Mitochondria
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231723000976
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