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Myeloid-derived suppressor cell-derived osteoclasts with bone resorption capacity in the joints of arthritic SKG mice

BackgroundMyeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells with immunosuppressive functions. It is known that MDSCs are expanded at inflammatory sites after migrating from bone marrow (BM) or spleen (Sp). In chronic inflammatory diseases such as rheumatoid arthritis...

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Principais autores: Yoshikazu Fujikawa, Sho Sendo, Alfonso del Peral Fanjul, Hirotaka Yamada, Kenichi Uto, Yuzuru Yamamoto, Takumi Nagamoto, Akio Morinobu, Jun Saegusa
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-03-01
Serier:Frontiers in Immunology
Fag:
MDSCs
SKG mice
osteoclastogenesis
arthritis
microarray
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1168323/full
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