The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

Huntington's disease (HD) is a devastating disorder that affects approximately 1 in 10,000 people and is accompanied by neuronal dysfunction and neurodegeneration. HD manifests as a progressive chorea, a decline in mental abilities accompanied by behavioural, emotional and psychiatric problems follo...

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Autors principals:	Noel J. Buckley, Rory Johnson, Chiara Zuccato, Angela Bithell, Elena Cattaneo
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2010-07-01
Col·lecció:	Neurobiology of Disease
Matèries:	Huntington's disease Hungtingtin Transcription Post-transcriptional RE1 silencing transcription factor (REST) Brain-derived-neurotrophic-factor (BDNF)
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996110000410
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