The Host NADase CD38 Promotes JEV Replication by Targeting the NAD+/SIRT1 Axis

The manipulation of host cellular metabolism is a key strategy for flaviviruses like Japanese encephalitis virus (JEV) to establish a productive infection. This study identifies the host NADase CD38 as a central regulator of this process. Using a CRISPR/Cas9-generated CD38 knockout (KO) TM3 cell mod...

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Principais autores:	Yuanyuan Yang, Ruiqin Zhang, Xinran Li, Xinlei Liu, Yu Dai, Yu Gu, Jiahui Li, Haodong Chen, Yi Zheng, Rui Wu
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2026-04-01
叢編:	Microorganisms
主題:	Japanese encephalitis virus CD38 NAD+ metabolism SIRT1/p53 axis
在線閱讀:	https://www.mdpi.com/2076-2607/14/4/796
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