A Polymorphism in the Gene Encoding Heat Shock Factor 1 (<i>HSF1</i>) Increases the Risk of Type 2 Diabetes: A Pilot Study Supports a Role for Impaired Protein Folding in Disease Pathogenesis

The aim of this pilot study was to investigate whether polymorphisms in the gene encoding heat shock factor 1 (<i>HSF1</i>), a transcriptional activator of molecular chaperones, play a role in the development of type 2 diabetes (T2D). A total of 3229 unrelated individuals of Slavic origin, including...

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Principais autores:	Elena Klyosova, Iuliia Azarova, Alexey Polonikov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-11-01
coleção:	Life
Assuntos:	type 2 diabetes mellitus genetic susceptibility molecular chaperons heat shock factor 1 (HSF1) single nucleotide polymorphism gene expression
Acesso em linha:	https://www.mdpi.com/2075-1729/12/11/1936
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