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A Polymorphism in the Gene Encoding Heat Shock Factor 1 (<i>HSF1</i>) Increases the Risk of Type 2 Diabetes: A Pilot Study Supports a Role for Impaired Protein Folding in Disease Pathogenesis

The aim of this pilot study was to investigate whether polymorphisms in the gene encoding heat shock factor 1 (<i>HSF1</i>), a transcriptional activator of molecular chaperones, play a role in the development of type 2 diabetes (T2D). A total of 3229 unrelated individuals of Slavic origin, including...

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Principais autores: Elena Klyosova, Iuliia Azarova, Alexey Polonikov
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-11-01
Serier:Life
Fag:
type 2 diabetes mellitus
genetic susceptibility
molecular chaperons
heat shock factor 1 (HSF1)
single nucleotide polymorphism
gene expression
Online adgang:https://www.mdpi.com/2075-1729/12/11/1936
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