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Defining cellular responses to HDAC-selective inhibitors reveals that efficient targeting of HDAC3 is required to elicit cytotoxicity and overcome naïve resistance to pan-HDACi in diffuse large B cell lymphoma

Approved histone deacetylase (HDAC) inhibitors have low efficacy against the most commonly-diagnosed non-Hodgkin lymphoma, diffuse large B cell lymphoma (DLBCL), but the mechanisms underlying clinical resistance are poorly understood. Using a DLBCL cell-based model, we previously demonstrated that r...

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Principais autores: Aaron P. Havas, Ana A. Tula-Sanchez, Hailey M. Steenhoek, Anvi Bhakta, Taylor Wingfield, Matthew J. Huntley, Angela S. Nofal, Tasmia Ahmed, Rosa Jaime-Frias, Catharine L. Smith
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-01-01
coleção:Translational Oncology
Assuntos:
Histone deacetylase
Lymphoma
Cell cycle
Apoptosis
Therapeutic resistance
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1936523323001651
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