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RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

Abstract Background The poor prognosis of subarachnoid hemorrhage (SAH) is often attributed to neuroinflammation. The cGAS-STING axis, a cytoplasmic pathway responsible for detecting dsDNA, plays a significant role in mediating neuroinflammation in neurological diseases. However, the effects of inhi...

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Principais autores: Jiang Shao, Yuxiao Meng, Kaikun Yuan, Qiaowei Wu, Shiyi Zhu, Yuchen Li, Pei Wu, Jiaolin Zheng, Huaizhang Shi
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-09-01
Serier:Cell Communication and Signaling
Fag:
Subarachnoid hemorrhage
Early brain injury
cGAS
STING
NF-κB
Microglia
Online adgang:https://doi.org/10.1186/s12964-023-01274-2
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