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Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C

The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in response to unattached kinetochores by generating a diffusible inhibitor termed the mitotic checkpoint complex (MCC). At metaphase, rapid activation of the APC/C requires removal of the MCC, a process...

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Principais autores: Dimitriya H. Garvanska, Marie Sofie Yoo Larsen, Jakob Nilsson
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2016-10-01
Serier:Biology Open
Fag:
UBE2C
UBE2S
APC/C
SAC silencing
APC15
MCC
Online adgang:http://bio.biologists.org/content/5/10/1441
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