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Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C

The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in response to unattached kinetochores by generating a diffusible inhibitor termed the mitotic checkpoint complex (MCC). At metaphase, rapid activation of the APC/C requires removal of the MCC, a process...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Dimitriya H. Garvanska, Marie Sofie Yoo Larsen, Jakob Nilsson
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2016-10-01
Schriftenreihe:Biology Open
Schlagworte:
UBE2C
UBE2S
APC/C
SAC silencing
APC15
MCC
Online-Zugang:http://bio.biologists.org/content/5/10/1441
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