DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility

Abstract DNA replication in differentiated cells follows a defined program, but when and how it is established during mammalian development is not known. Here we show using single-cell sequencing, that late replicating regions are established in association with the B compartment and the nuclear lam...

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Bibliografski detalji

Glavni autori:	Shuangyi Xu, Ning Wang, Michael V. Zuccaro, Jeannine Gerhardt, Rajan Iyyappan, Giovanna Nascimento Scatolin, Zongliang Jiang, Timour Baslan, Amnon Koren, Dieter Egli
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2024-06-01
Serija:	Nature Communications
Online pristup:	https://doi.org/10.1038/s41467-024-49565-7
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