Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint

Summary: Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show that Shigella IpaA triggers major allosteric changes in...

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Autors principals:	Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, Christophe Le Clainche, Christian Malosse, Diogo Borges Lima, Nicole Quenech’Du, Bilal Mazhar, Sami Essid, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran Van Nhieu
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-04-01
Col·lecció:	Cell Reports
Matèries:	CP: Microbiology CP: Cell biology
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124723004163
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