Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint

Summary: Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show that Shigella IpaA triggers major allosteric changes in...

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Detalhes bibliográficos

Principais autores:	Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, Christophe Le Clainche, Christian Malosse, Diogo Borges Lima, Nicole Quenech’Du, Bilal Mazhar, Sami Essid, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran Van Nhieu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-04-01
coleção:	Cell Reports
Assuntos:	CP: Microbiology CP: Cell biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124723004163
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