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Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling

Background: Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. Methods: We used immunohistochemistry, western blotting and quantitative...

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Principais autores: Xiang Hu, Long Zhang, Yaqi Li, Xiaoji Ma, Weixing Dai, Xiaoxue Gao, Xinxin Rao, Guoxiang Fu, Renjie Wang, Mengxue Pan, Qiang Guo, Xiaoya Xu, Yi Zhou, Jianjun Gao, Zhen Zhang, Sanjun Cai, Junjie Peng, Guoqiang Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-06-01
coleção:EBioMedicine
Assuntos:
DACH1
Organoid
Stem cells
BMP signalling pathway
Colorectal cancer
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396420301754
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