CRISPR/Cas9-mediated knock-in of the murine Y chromosomal genes Zfy1 and Zfy2

Abstract Background The Y-linked mouse zinc finger genes Zfy1 and Zfy2 are critical fertility factors in mice but the mechanisms by which they regulate spermatogenesis remain unclear. We recently produced Zfy1/2 double knock-out mice and observed a complete loss in fertility. However, the biochemica...

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Principais autores:	Hayden Holmlund, Yasuhiro Yamauchi, Muhammetnur Tekayev, Sydney Jakobs, Antoine Robin, Wataru Fujii, Monika A. Ward
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-12-01
叢編:	BMC Genomics
主題:	Spermatogenesis Sperm Testis Y chromosome Knock-in CRISPR/Cas9
在線閱讀:	https://doi.org/10.1186/s12864-025-12462-4
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