A novel PDHK inhibitor restored cognitive dysfunction and limited neurodegeneration without affecting amyloid pathology in 5xFAD mouse, a model of Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is the most common form of dementia. Although drugs focusing on reducing amyloid β slow progression, they fail to improve cognitive function. Deficits in glucose metabolism are reflected in FDG-PET and parallel the neurodegeneration and synaptic marker lo...

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Detalhes bibliográficos

Principais autores:	Katsuya Sakimura, Takashi Kawai, Reiko Nashida, Yuji Ishida, Kana Harada, Takashi Suzuki, Chihiro Okuma, Gregory M. Cole
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-09-01
Colecção:	Alzheimer’s Research & Therapy
Assuntos:	Alzheimer’s disease Pyruvate dehydrogenase (PDH) Pyruvate dehydrogenase kinase (PDHK) 5xFAD Glucose metabolism Aerobic glycolysis
Acesso em linha:	https://doi.org/10.1186/s13195-024-01552-2
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