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Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice

Abstract The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the impact of donepezil on tau pathology is unclear. Thus, we examined the effects of donepezil on Aβ and tau pathology in 5xFAD mice (a model of...

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Principais autores: Hee-Jeong Choi, Jin-Hee Park, Yoo Joo Jeong, Jeong-Woo Hwang, Soojung Lee, Heeyong Lee, Eunyoung Seol, Ik-whi Kim, Byung-Yoon Cha, Jinsoo Seo, Minho Moon, Hyang-Sook Hoe
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-07-01
Colecção:Molecular Brain
Assuntos:
Alzheimer’s disease
Tau
Tau kinase
Amyloid beta
5xFAD mice
Donepezil
Acesso em linha:https://doi.org/10.1186/s13041-022-00948-1
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