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Optimizing aspirin dose for colorectal cancer patients through deep phenotyping using novel biomarkers of drug action

Background: Low-dose aspirin’s mechanism of action for preventing colorectal cancer (CRC) is still debated, and the optimal dose remains uncertain. We aimed to optimize the aspirin dose for cancer prevention in CRC patients through deep phenotyping using innovative biomarkers for aspirin’s action.Me...

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Principais autores: Paola Patrignani, Stefania Tacconelli, Annalisa Contursi, Elena Piazuelo, Annalisa Bruno, Stefania Nobili, Matteo Mazzei, Cristina Milillo, Ulrika Hofling, Gonzalo Hijos-Mallada, Carlos Sostres, Angel Lanas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-02-01
Serier:Frontiers in Pharmacology
Fag:
colorectal cancer
biomarker-based aspirin dose optimization
thromboxane A2
prostaglandin E2
cyclooxygenases
platelets
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2024.1362217/full
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