The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of isc...

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Principais autores:	Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nieman, Steven E. McKenzie, Christian Con Yost, Leslie A. Lange, Mary Cushman, Marguerite R. Irvin, Paul F. Bray, Robert A. Campbell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2023-09-01
coleção:	The Journal of Clinical Investigation
Assuntos:	Hematology Neuroscience
Acesso em linha:	https://doi.org/10.1172/JCI169608
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