The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes
Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of isc...
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| Główni autorzy: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2023-09-01
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| Seria: | The Journal of Clinical Investigation |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1172/JCI169608 |
| Etykiety: |
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