SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

Abstract Synucleinopathies, including Parkinson’s disease, involve α-synuclein (SNCA) accumulation and neurodegeneration, but early molecular effects of increased SNCA dosage remain incompletely defined. We examined human midbrain organoids derived from induced pluripotent stem cells carrying SNCA t...

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Autori principali:	Elpida Statoulla, Maria Zafeiri, Kleanthi Chalkiadaki, Georgia Voudouri, Karmel S. Gkika, Christos Papazoglou, Thomas M. Durcan, Arkady Khoutorsky, Seyed Mehdi Jafarnejad, Sarah Maguire, Alexander Dityatev, Christos G. Gkogkas
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-02-01
Serie:	npj Parkinson's Disease
Accesso online:	https://doi.org/10.1038/s41531-026-01292-0
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