Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.

The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may therefore provide routes for therapies targeting the underlying mutation, an approach that is likely applicable to other trinucleotide repeat dise...

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Bibliografiske detaljer

Principais autores:	Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St Claire, Gagan B Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis, Jolene R Guide, Paula E Cohen, Guo-Min Li, Christopher E Pearson, Mark J Daly, Vanessa C Wheeler
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2013-10-01
Serier:	PLoS Genetics
Online adgang:	http://europepmc.org/articles/PMC3814320?pdf=render
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