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Early motor deficits, sleep dysfunction and reduction in dopaminergic neurons in a PARK7-/- zebrafish larval model of Parkinson’s disease

Abstract Parkinson’s Disease (PD) is the fastest-growing neurological disorder and only symptomatic treatment is available. Zebrafish are ideally suited for high-throughput screening of disease modifying drugs and mechanistic studies. Mutations in PARK7 are associated with early onset familial PD, h...

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Principais autores: Nora Solheim, Brígida R. Pinho, Nuno A. S. Oliveira, Leonor P. Lima, Aina Børve, Jorge M. A. Oliveira, Kari E. Fladmark
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-02-01
Serier:Scientific Reports
Fag:
Parkinson’s disease
Zebrafish model
Sleep
Motor
Non-motor
Prodromal
Online adgang:https://doi.org/10.1038/s41598-026-39692-0
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